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Is NUCLEASE a valid Scrabble word?

Yes, NUCLEASE is a valid word in US Scrabble and UK Scrabble, worth 10 points.

Base score before bonus squares; blank tiles score zero.

What does NUCLEASE mean?

  1. noun

    general term for enzymes that catalyze the hydrolysis of nucleic acid by cleaving chains of nucleotides into smaller units

Definitions from WordNet 3.1, Princeton University.

Points

10

Scrabble

14

Words With Friends

8

Letters

N (1) + U (1) + C (3) + L (1) + E (1) + A (1) + S (1) + E (1) = 10 points in Scrabble.

Dictionary status

  • Scrabble (US & Canada)Valid
  • Scrabble (UK & worldwide)Valid
  • Words With FriendsListed

Scrabble lists: NWL2023 (US & Canada) and CSW24 (UK & worldwide). WWF uses our ENABLE reference plus verified additions. “Listed” and “Not listed” describe that reference; check acceptance in the game. Sources reviewed 2026-10-03.

Hooks for NUCLEASE

Single letters that turn NUCLEASE into another valid word in US Scrabble. Hooks let you extend a word already on the board.

Front hooks0

None — nothing can be added to the front.

Back hooks1

Words you can make from NUCLEASE

The 60 highest-scoring words using these letters.

Study NUCLEASE and related words

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