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Is METHOTREXATE a valid Scrabble word?

Yes, METHOTREXATE is a valid word in US Scrabble and UK Scrabble, worth 24 points.

Base score before bonus squares; blank tiles score zero.

What does METHOTREXATE mean?

  1. noun

    toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis

Definitions from WordNet 3.1, Princeton University.

Points

24

Scrabble

24

Words With Friends

12

Letters

M (3) + E (1) + T (1) + H (4) + O (1) + T (1) + R (1) + E (1) + X (8) + A (1) + T (1) + E (1) = 24 points in Scrabble.

Dictionary status

  • Scrabble (US & Canada)Valid
  • Scrabble (UK & worldwide)Valid
  • Words With FriendsListed

Scrabble lists: NWL2023 (US & Canada) and CSW24 (UK & worldwide). WWF uses our ENABLE reference plus verified additions. “Listed” and “Not listed” describe that reference; check acceptance in the game. Sources reviewed 2026-10-03.

Hooks for METHOTREXATE

Single letters that turn METHOTREXATE into another valid word in US Scrabble. Hooks let you extend a word already on the board.

Front hooks0

None — nothing can be added to the front.

Back hooks1

Words you can make from METHOTREXATE

The 60 highest-scoring words using these letters.

Study METHOTREXATE and related words

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